The Impact of Disease and Illness on the Native Populations of North America

Using the Mandan Tribe as a case study, examine the impact of disease and illness on the Native populations of North America over the long colonial period (1600s through 1800s). I'm your essay take into account such issues as demographic decline, social tension within communities, and intertribal warfare. In your opinion, how important was disease to the struggles that Mandan people faced?
Using the book and reading "Encounters at the Heart of the World" by Elizabeth Fenn